@article{Romesh Kumar Jaiswal*_Manisha Dikshit_Ramesh Chandra Tiwari_Ved Bhushan Sharma_2019, place={India.}, title={A STUDY ON VISHAGHNA PROPERTY OF SHANKHPUSHPI (CONVOLVULUS PLURICAULIS CHOIS) W.S.R. TO SUB ACUTE TOXICITY IN ALBINO WISTAR RATS }, volume={6}, url={https://ayushdhara.in/index.php/ayushdhara/article/view/473}, abstractNote={<p><em>Shankhpushpi </em>(<em>Convolvulus pluricaulis</em> chois) is an indigenous and very significant herb which is considered as a gift of nature in Ayurveda. In Ayurvedic literature, <em>Shankhpushpi </em>is considered as <em>Medhya rasayana</em> means it enhances the knowledge, memory and retaining power of a person. <em>Shankhpushpi</em> which is well described and abundantly available is taken for the <em>Vishaghna</em> property also. Although, the <em>Medhya</em> property of <em>Shankhpushpi</em> is well marketed and used by different pharmaceutical companies but, the <em>Vishaghna</em> property of this miraculous drug should be researched and established as it may fulfil the long awaited gap of Ayurvedic antitoxic substance(<em>Agad</em>).</p> <p>In this study 24 albino wistar rats were divided in four groups such as group G1, G2, G3 &amp; G4 with 6 rats in each group. Group G2, G3 &amp; G4 had received PCM in dose 1000mg/kg body weight for 7 days to induce hepato-nephro toxicity while group G1 was normal control group which was kept on normal feeding. After inducing hepato-nephro toxicity the sample drug <em>Shankhpushpi</em> in Group G2 in the form of <em>Churna</em> and in group G3 in the form of aqueous extract (<em>Kwatha</em>) was administered while in group G4 only normal saline was administered for 28 days. On the basis of study it can be concluded that toxicity induced by 1000mg/kg body weight PCM did not cause any neurological manifestations. After 28 days administration of drug <em>Shankhpushpi Churna</em> as well as <em>Kwatha</em> in group G2 &amp; group G3, body weight and food consumption in this group slightly increased while in group G4 no any significant changes were found. Therapeutic administration of <em>Shankhpushpi </em>as <em>Churna</em> as well as<em> Kwatha </em>significantly decreased PCM induced toxicity.</p>}, number={4}, journal={AYUSHDHARA}, author={Romesh Kumar Jaiswal* and Manisha Dikshit and Ramesh Chandra Tiwari and Ved Bhushan Sharma}, year={2019}, month={Nov.}, pages={2279-2285} }