Evaluation of Vanadhanyaka (Eryngium Foetidum Linn.), A Folklore Drug on Mukhadushika (Acne Vulgaris) - An In-Vitro Study

Abstract

Face is the index of body and mind. It is the general opinion that smooth and glowing skin of face not only enhances the beauty of a person but it also adds self-confidence. In Ayurvedic classics in the context of Kshudra rogas, Mukhadushika is mentioned. Its signs and symptoms are similar to that of acne vulgaris. One of the causative bacteria is Staphylococcus epidermidis. But at present effective medication or preventive measures with less side effects are very few. So, there is a need for one. Vanadhanyaka (Eryngium foetidum Linn.) is one such drug, which is endowed with a property of antibacterial, anti-inflammatory, analgesic and antioxidant. Phytochemical screening of the leaves indicated the presence of flavonoids, polyphenolic compounds, saponin, phytosteroids, triterpenoids, alkaloids, tannins anthraquinones, cardiac glycosides and terpenes. Eryngium foetidum Linn extracts were carried out. The whole plant was used for the in vitro experiment. The aqueous, alcoholic and hexane extract of the trial drug was tested against the Staphylococcus epidermidis bacteria MTCC (Microbial Type Culture Collection and Gene Bank)435. The in-vitro studies to determine the minimum inhibitory concentration was done by micro-broth dilution method and zone of inhibition by Agar well diffusion method. Hexane extract showed better results compare to alcoholic and aqueous extracts.