Ayurvedic Insights into Ocular Allergy: Therapeutic Role of Gutika Anjana and Shirisha Avaleha in VKC

Abstract

Vernal keratoconjunctivitis (VKC), corresponding to Kaphaja Abhishyanda in Ayurveda, is a chronic allergic ocular disorder primarily affecting children and adolescents. Current treatments often involve drugs with preservatives that may cause toxicity, highlighting the need for safe, effective alternatives. Objective: To evaluate the clinical efficacy of Gutika Anjana (ocular ointment) and Shirisha Avaleha (oral formulation) in the management of Kaphaja Abhishyanda. Materials and Methods: A single-group clinical study was conducted on 30 patients (5–30 years) diagnosed with Kaphaja Abhishyanda. Patients received Gutika Anjana twice daily in the lower fornix and age-adjusted doses of Shirisha Avaleha orally for 30 days. Subjective parameters (Guruta, Kandu, Updeha, Muhumuhusrava, photophobia, burning sensation) and objective parameters (palpebral and bulbar conjunctival congestion and hypertrophy, Horner’s Tranta’s spots) were assessed pre- and post-treatment. Results: Significant improvements were observed in all subjective symptoms: Guruta (62–63.5%), Kandu (46%), Updeha (50–62.9%), Muhumuhusrava (63%), Photophobia (40%), and burning sensation (40–42%) (P<0.001). Palpebral conjunctival congestion improved by 45–46% (P< 0.001), and bulbar conjunctival congestion resolved completely (100%, P<0.05). Changes in palpebral conjunctival hypertrophy were modest and statistically insignificant, while bulbar hypertrophy and Horner’s Tranta’s spots remained unchanged. Conclusion: The combined therapy of Gutika Anjana and Shirisha Avaleha is effective in relieving clinical symptoms and reducing ocular inflammation in Kaphaja Abhishyanda. Gutika Anjana acts locally to alleviate ocular signs, while Shirisha Avaleha provides systemic anti-allergic and immunomodulatory effects, making this regimen a safe and effective Ayurvedic approach for VKC.