Evaluating the Efficacy of Haridradi Lepa in the Treatment of Sarvasara Mukhapaka: A Clinical Study with Focus on Inflammatory Oral Mucosal Conditions

Abstract

Mukhapaka is one among diseases mentioned under Mukha Rogas (diseases of oral cavity) where vitiated Vatadi Doshas will give rise to Shotha (inflammation) or Vrana (ulcer) which are similar with inflammatory oral mucosal conditions. Sthanika Chikitsa as Haridra Yashtimadhu Kumari Lepa (topical paste) was selected as trial drug and its efficacy was compared with Triamcinolone Acetonide 0.1% oral gel which is a commonly used and previously researched drug. A forethought was given on the patient’s quality of life, drug’s literary pharmacological review, convenience of availability and usage, trends of effect on long term usage of control drug, preservative free drug preparation and compatibility to oral pH value. Aims and Objectives: To evaluate the role of Haridra Yashtimadhu Kumari Lepa in the management of Mukhapaka. The objective of the study was to evaluate and re-evaluate the efficacy of both the drugs and also to compare both. Secondary objectives were to assess improvement in quality of life based on subjective parameters International OHR QOL questionnaire and the objective parameters - size of Mukhapaka and colorimetry. Materials and methods: Thirty subjects fulfilling the inclusion criteria were randomly divided and equally assigned to two groups A and B. Group A was given trial drug- Haridra Yashtimadhu Kumari Lepa and Group B was given control drug- Triamcinolone Acetonide 0.1% oral gel. Both the drugs were given to be used as topical application at the affected oral mucosal region, bed time for seven days. Statistical evaluation was done using Sigma stat version 3.1 and IBM SPSS Version 26. Results: Both the groups showed statistically significant improvement in the condition and no statistical difference in between the groups. There were clinically better results from group A in comparison with group B. Conclusion: Though null hypothesis is accepted, group A showed clinically better results.