Clinical Outcomes of Gomutra Bhavitha Chitraka Rasayana in Progressive Supranuclear Palsy: Evidence from an Ayurvedic Single Case

Abstract

Progressive Supranuclear Palsy (PSP) is a rare, progressive neurodegenerative disorder characterized by postural instability, gait disturbances, oculomotor dysfunction, speech impairment, and dysphagia. From an Ayurvedic perspective, the clinical presentation of PSP closely resembles Kaphavrita Vyana Vata based on symptomatology. A 52-year-old male presented to the Kayachikitsa OPD at Government Ayurveda Medical College, Tripunithura, Kerala, with recurrent backward falls, gait imbalance, slurred speech, axial rigidity, impaired eye movements, and emotional blunting. Following inpatient admission, the diagnosis of PSP was confirmed through MRI brain imaging. Considering the Avarana-dominant pathology, treatment principles of Avaranavata were adopted initially. As PSP represents a progressive neurodegenerative condition, Rasayana therapy was integrated within the framework of classical Vatavyadhi management. After appropriate Shodhana, Chitraka Rasayana, described in the Rasayana chapter of Ashtanga Hridaya, was administered owing to its Ushna, Tikshna, and Srotoshodhaka properties. Disease assessment using the Progressive Supranuclear Palsy Rating Scale (PSPRS) demonstrated significant improvement, with scores reducing from 65 at baseline to 36 after one month of Rasayana therapy. This case highlights the potential role of individualized Ayurvedic interventions in improving functional status and quality of life in PSP.