Ayurvedic Intervention in Mixed Connective Tissue Disease: Therapeutic Strategy for Systemic Manifestations

Abstract

Ayurveda interprets conditions under the spectrum of Tridoshaja Vyadhi with predominance of Vata-Pitta Dosha, Raktavaha Srotas Dusti, and Ama formation, resulting in systemic inflammation and tissue degeneration. The present case study evaluates the efficacy of an integrative Ayurvedic therapeutic approach in a 41-year-old female patient presenting with severe polyarticular pain, swelling, stiffness, functional disability, and systemic symptoms. The treatment protocol included Deepana-Pachana, Snehapana with Triphala Ghrita, followed by Virechana Karma using Icchabhedi Rasa, and Basti Karma with Guduchyadi and Yashtimadhvadi Niruha Basti. Post-procedural management involved administration of Guduchi, Simhanada Guggulu, Kaishore Guggulu, and Punarnavadi Kashaya for one month. Following the intervention, marked improvement was observed in clinical parameters, with significant reduction in joint pain, swelling, tenderness, and morning stiffness. Functional capacity improved notably, as the patient regained the ability to walk independently and demonstrated enhanced grip strength. Laboratory findings revealed a reduction in RA factor value, indicating decreased inflammatory activity. Additionally, systemic symptoms such as fever, poor appetite, and digestive disturbances were resolved. This case highlights that an integrative Ayurvedic approach incorporating Shodhana and Shamana Chikitsa may offer a promising therapeutic strategy in the management of MCTD by addressing the underlying pathophysiology, improving clinical outcomes, and enhancing quality of life.